acetyl-l-carnitine - this one seems like a no-brainer to me. numerous studies have demonstrated that it significantly enhances peripheral nerve generation (by 2000% in one study). local injections to the area might be particularly effective, but they sting
ginsenosides from panax ginseng have shown efficacy in enhancing, nerve growth factor dependent and independent, neurite outgrowth in some cell cultures. unfortunately i'm not aware of any in vivo studies dealing specifically w/ peripheral nerve regeneration.
idebenone is a potent stimulator of nerve growth factor secretion in astrocyte cultures, but i'm not aware of any studies that demonstrate this effect in other tissues.
IGF-1 and nerve growth synergisticly enhance neurite outgrowth in sensory neurons. local administration of either might be beneficial. IGF-1 isn't hard to obtain, but NGF is a different story. Something to ask your docs about maybe?
More important than any of this is trying to use the disabled limb on a regular basis. The act of trying to send signals to the injured limb is critical. Immobilizing the functional limb can help force you to use the disabled one. They do this for arms, not sure about with legs.
source: http://www.mindandmuscle.net/forum/lofiversion/index.php/t7634.html
At this point, undoing the damage requires a rather extensive list of very expensive supplements and a lot of conjecture.
ResponderEliminarGlutathione increases neuronal receptor sensitivity, so increasing glutathione levels will allow the remaining receptors to function optimally. Intravenous glutathione works for some people with PD, but getting glutathione into the brain and into the cells is not easy. Consequently, indirect ways of raising glutathione are probably a better approach. Lipoic Acid, I prefer K-R-ALA, will raise intracellular and serum glutathione. There are many good threads here about Lipoic Acid. N-Acetyl Cysteine raises glutathione levels too.
Activators of Nrf2 and the Antioxidant Response Element promoter portion of DNA, such as curcumin, sulforaphane, acetyl-L-carnitine, Lipoic Acid are potent inducers of not only glutathione, but catalase and a host of other detoxifying enzymes in the body.
Acetyl L-Carnitine also increases dopamine release, neurogenesis, mitochondrial respiration. The mitochondrial respiration angle appears to be crucial to the damage done by meth, because meth appears to be a proteasome inhibitor and mitochondrial transport chain inhibitor.
Thankfully, activators of Nrf2/ARE also increase proteasome activity. Proteasomes target damaged proteins and metabolize them for recycling or export.
Fish oil, EPA/DHA increase BDNF levels and thus stimulates neurogenesis. Much more can be said about the beneficial effects of fish oil on neuronal function, including membrane fluidity, etc.
As far as regenerating neurons go, nothing appears to be as powerful as exercise in increasing levels of neural growth factors such as BDNF, NGF, GDNF.
source: http://www.mindandmuscle.net/forum/lofiversion/index.php/t15126.html
http://answers.google.com/answers/threadview?id=250339
ResponderEliminar